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CROWN: 1L lorlatinib improves PFS, reduces CNS progression in ALK-positive NSCLC ± brain metastases

09 Sep 2022 by

First-line treatment of ALK-positive non-small-cell lung cancer (NSCLC) with lorlatinib improves progression-free survival (PFS) and reduces central nervous system (CNS) progression vs crizotinib, regardless of presence or absence of baseline brain metastases (BM), a post hoc analysis of the phase III CROWN trial has shown.

09 Sep 2022

3D VR models help improve outcomes for patients undergoing robotic prostatectomy

08 Sep 2022 by

Patients whose surgical planning for robotic-assisted laparoscopic radical prostatectomy (RALP) involved 3-dimensional (3D) virtual reality (VR) models experience better oncologic outcomes without compromising functional outcomes, reports a recent study.

08 Sep 2022

Intravesical pembrolizumab delivers antitumour activity in NMIBC

08 Sep 2022 by

A recent first-in-human study has shown that directly applying pembrolizumab to the bladder is a safe and effective treatment option for patients with nonmuscle-invasive bladder cancer (NMIBC) who are unresponsive to bacillus Calmette-Guérin (BCG) treatment.

08 Sep 2022

Trabectedin fails to improve survival outcomes in recurrent ovarian, primary peritoneal, or fallopian tube cancer

07 Sep 2022 by

Trabectedin did not improve overall survival (OS) or progression-free survival (PFS) compared with chemotherapy in women with recurrent ovarian, primary peritoneal, or fallopian tube cancer and BRCA mutation or BRCAness phenotypes, according to results of the phase III MITO23 trial.

07 Sep 2022

ART conception may pose risk of childhood cancers

07 Sep 2022 by

Children born via assisted reproductive technology (ART) may be at higher risk of developing cancers compared with their counterparts who were conceived naturally or born to parents with an infertility, as shown in a recent study from Taiwan.

07 Sep 2022

Anal HSIL treatment key to anal cancer prevention in PLHIV?

07 Sep 2022 by

In persons living with HIV (PLHIV) with anal high-grade squamous intraepithelial lesions (HSIL), treatment of the lesions reduced the risk of progression to anal cancer compared with active monitoring, the phase III ANCHOR* trial has shown.

07 Sep 2022

Postoperative delirium tied to worse surgical outcomes in older adults

07 Sep 2022

In older adults undergoing elective abdominal cancer resection, postoperative delirium (POD) appears to lead to poor surgical outcomes, a recent Taiwan study has found.

07 Sep 2022

Early everolimus boosts tumour control in TSC-related angiomyolipoma

06 Sep 2022

In patients with tuberous sclerosis complex (TSC), early everolimus intervention for neuronal lesions leads to better tumour control of renal angiomyolipoma (AML) and lower side effects, a recent study has found.

06 Sep 2022