News & Updates

The novel partial μ receptor agonist and full κ receptor antagonist ORP-101 has failed to demonstrate superiority to placebo in the treatment of patients with irritable bowel syndrome (IBS) with diarrhoea (IBS-D) in a phase II randomized controlled trial.

Receiving nonoperative management (NOM) and overall survival (OS) among patients with rectal adenocarcinoma are associated with several demographic factors and social determinants of health, according to a study.

Using glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may reduce the risk of liver outcomes, death, and harmful alcohol use in patients with alcohol use disorder, reveals a study.

Metformin users appear to have a reduced risk of esophageal squamous cell carcinoma (ESCC) compared with nonusers, as shown in a population-based study.

High consumption of apple, pear, banana, mushrooms, onion, and garlic may reduce the risk of developing Crohn’s disease (CD), while a high intake of potatoes may induce the development of ulcerative colitis (UC), a study has shown.

In patients with primary biliary cholangitis (PBC) with insufficient response to ursodeoxycholic acid, outcomes appear to improve following treatment with fenofibrate, as shown in a single-centre retrospective cohort study.

Treatment with upadacitinib induces clinical remission and endoscopic improvement in most patients with severe, refractory Crohn’s disease (CD) or ulcerative colitis (UC) with prior tofacitinib failure, regardless of previous response to tofacitinib, a study has shown.

A tissue transglutaminase (tTG) value of >5.5 upper the normal level (UNL) attained a specificity of 100 percent for the prediction of duodenal atrophy in patients with coeliac disease (CeD), reports a study. This cutoff value may be used to bypass the need for diagnostic endoscopy in adults suspected of CeD.

Gastroesophageal reflux disease (GERD) and its complications appear to increase the risk of nontuberculous mycobacterium (NTM) infection, suggests a study.