YSP Clonidine: Dosing, Side Effect & Interaction

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Side Effects Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Clonidine HCl

Indications/Uses

Acute hypertensive crisis.

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Dosage/Direction for Use

1-2 amp (150-300 mcg) via slow IV or IM inj over 5 min, may be repeated at 3-6 hr intervals as needed.

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Overdosage

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Contraindications

Hypersensitivity. Severe bradyarrhythmia resulting from either sick sinus syndrome or 2nd- or 3rd-degree AV block.

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Warnings

For additional cautionary notes to warn of the potential risk of using the medicine... Click to view YSP Clonidine detailed prescribing information

Special Precautions

History of depression or advanced cerebrovascular disease; clinical DM; mild to moderate bradyarrhythmia eg, low sinus rhythm, cerebral or peripheral perfusion disorders, polyneuropathy & constipation; heart failure or severe CHD. May cause decreased lacrimation in contact lens wearer. Discontinue use for 7 days prior to anaesth use. Avoid abrupt w/drawal. Prolonged & high-dose use. Not to be taken by patients w/ galactose intolerance eg, galactosaemia. Concurrent administration of TCAs. May affect ability to drive & use machines. Hepatic or renal impairment. Avoid use during pregnancy. Not to be used during lactation. Not to be used in neonates. Not recommended in childn & adolescents. Avoid use in childn <2 yr.

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Use In Pregnancy & Lactation

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Adverse Reactions

Dizziness, sedation; orthostatic hypotension; dry mouth. Depression, sleep disorder; headache; constipation, nausea, salivary gland pain, vomiting; erectile dysfunction; fatigue.

Drug Interactions

Potentiated effects of alcohol, sedatives, hypnotics or other centrally-active substances. Reduced therapeutic effect by NSAIDs. Abolished α₂-adrenergic receptor-mediated effects w/ α₂-adrenergic receptor blockers eg, phentolamine. Potentiated bradycardic rhythm disturbances w/ β-blockers, digitalis glycosides. Potentiated peripheral vascular disorders by β-blockers. Reduced or abolished effects & provoked or aggravated orthostatic regulation disturbances w/ TCAs, neuroleptics w/ α-receptor blockers. Increased arrhythmogenic potential of high-dose IV haloperidol.

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Caution For Usage

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Storage

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Description

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Action

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MIMS Class

Other Antihypertensives

ATC Classification

C02AC01 - clonidine ; Belongs to the class of imidazoline receptor agonists, centrally-acting antiadrenergic agents. Used in the treatment of hypertension.

Regulatory Classification

Presentation/Packing

Form

YSP Clonidine soln for inj 150 mcg/mL

Packing/Price

1 mL x 5 × 1's

YSP Clonidine

clonidine

Manufacturer:

Y.S.P. Industries

Distributor:

Y.S.P. Industries