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Additive in total parenteral nutrition
Adult: As additive to amino acid solutions to meet the nutritional requirement in patients with severe liver disease who may have impaired enzymatic processes and require TPN: For stable and critically ill patients: 7 mg cysteine hydrochloride/g of amino acids (equivalent to 4.8 mg cysteine/g of amino acids) daily. Doses are given as an admixture into parenteral nutrition solutions; then the resulting solution is given via IV infusion into a central or peripheral vein depending on the osmolarity. Solutions with osmolarity of ≥900 milliosmole/L must be infused via a central catheter. Individualise dose based on patient's clinical condition, daily protein (amino acids) or nutritional/fluid requirements, weight, and additional energy given via oral or enteral route.
Child: As additive to amino acid solutions to meet the nutritional requirements in infants requiring TPN, and in children with severe liver disease who may have impaired enzymatic processes and require TPN: Infants Usual dose: 30-40 mg cysteine hydrochloride/g of amino acids daily; a low dose of 20 mg cysteine hydrochloride/g of amino acids daily may be sufficient. Alternatively, 22 mg cysteine hydrochloride/g of amino acids (equivalent to 15 mg cysteine/g of amino acids) daily. 1-11 years 22 mg cysteine hydrochloride/g of amino acids (equivalent to 15 mg cysteine/g of amino acids) daily. ≥12 years 7 mg cysteine hydrochloride/g of amino acids (equivalent to 4.8 mg cysteine/g of amino acids) daily. Doses are given as an admixture into parenteral nutrition solutions; then the resulting solution is given via IV infusion into a central or peripheral vein depending on the osmolarity. Solutions with osmolarity of ≥900 milliosmole/L must be infused via a central catheter. Individualise dose based on patient's clinical condition, daily protein (amino acids) or nutritional/fluid requirements, weight, and additional energy given via oral or enteral route. Dosage recommendations may vary between local guidelines (refer to institution-specific protocols).
Child: As additive to amino acid solutions to meet the nutritional requirements in infants requiring TPN, and in children with severe liver disease who may have impaired enzymatic processes and require TPN: Infants Usual dose: 30-40 mg cysteine hydrochloride/g of amino acids daily; a low dose of 20 mg cysteine hydrochloride/g of amino acids daily may be sufficient. Alternatively, 22 mg cysteine hydrochloride/g of amino acids (equivalent to 15 mg cysteine/g of amino acids) daily. 1-11 years 22 mg cysteine hydrochloride/g of amino acids (equivalent to 15 mg cysteine/g of amino acids) daily. ≥12 years 7 mg cysteine hydrochloride/g of amino acids (equivalent to 4.8 mg cysteine/g of amino acids) daily. Doses are given as an admixture into parenteral nutrition solutions; then the resulting solution is given via IV infusion into a central or peripheral vein depending on the osmolarity. Solutions with osmolarity of ≥900 milliosmole/L must be infused via a central catheter. Individualise dose based on patient's clinical condition, daily protein (amino acids) or nutritional/fluid requirements, weight, and additional energy given via oral or enteral route. Dosage recommendations may vary between local guidelines (refer to institution-specific protocols).
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