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AstraZeneca-Oxford COVID-19 vaccine 79 percent effective in US trial

28 Mar 2021 by

The COVID-19 vaccine AZD1222 by AstraZeneca and the University of Oxford was 79 percent effective overall in preventing symptomatic infections – higher than observed in previous clinical trials of the vaccine – at the interim analysis of a US phase III trial.

AstraZeneca-Oxford COVID-19 vaccine 79 percent effective in US trial

28 Mar 2021

Longer interval between doses of COVID-19 vaccines: A gamble worth taking?

27 Mar 2021 by

Despite the increasing pace of COVID-19 vaccine rollout around the world, one stark reality remains — cases have been on the rise in many countries while vaccine availability still markedly falls short of the required population coverage to warrant mass protection.

Longer interval between doses of COVID-19 vaccines: A gamble worth taking?

27 Mar 2021

High fluctuation seen in anticoagulants use, off-label dosing stable

27 Mar 2021

A recent study has found an increasing number of existing oral anticoagulation regimes being changed to apixaban, but the proportion of off-label dosages of all oral anticoagulants remains stable.

High fluctuation seen in anticoagulants use, off-label dosing stable

27 Mar 2021

PDE5i therapy lowers risk of heart failure, death in men with CAD

26 Mar 2021 by

Treatment with phosphodiesterase 5 inhibitor (PDE5i) appears to reduce the risk of death, myocardial infraction (MI), heart failure, and revascularization in men with stable coronary artery disease (CAD) as compared to alprostadil therapy, a study has found.

PDE5i therapy lowers risk of heart failure, death in men with CAD

26 Mar 2021

Metabolic surgery better than meds for T2D control?

25 Mar 2021 by

Metabolic surgery may be a suitable treatment option for type 2 diabetes (T2D), with a greater likelihood of remission, lower requirement for glucose-control medications, and fewer diabetes-related complications compared with medical therapy, according to long-term follow-up of a small Italian trial.

Metabolic surgery better than meds for T2D control?

25 Mar 2021

Should women stop antidepressant treatment during pregnancy?

25 Mar 2021

A re-evaluation of psychiatric treatment is needed for pregnant women treated with antidepressant, suggests a recent study, noting the necessity for focusing on obstetric complications for severely depressed women.

Should women stop antidepressant treatment during pregnancy?

25 Mar 2021

Margetuximab bests trastuzumab in advanced breast cancer

25 Mar 2021 by

Adding margetuximab – a novel chimeric Fc-engineered anti-ERBB2* antibody – to single-agent chemotherapy (CT) yielded better survival benefit and favourable safety compared with the trastuzumab-CT regimen for women with pretreated ERRB2-positive advanced breast cancer (ERRB2+ ABC), according to the initial results of the phase III SOPHIA trial.

Margetuximab bests trastuzumab in advanced breast cancer

25 Mar 2021

Predictors of main bleeding following ticagrelor

25 Mar 2021

In patients with acute coronary syndrome who underwent coronary stent implantation, the incidence of major bleeding after ticagrelor therapy is associated with low body weight, anaemia, and chronic kidney disease, a study reports.

Predictors of main bleeding following ticagrelor

25 Mar 2021

Hope in sight for an oral antiviral pill against COVID-19

24 Mar 2021 by

The oral antiviral drug molnupiravir, given for 5 days, eliminated SARS-CoV-2 in the nasopharynx of patients with COVID-19, interim results of a phase IIa study have shown, boosting hopes for its potential use in the outpatient setting.

Hope in sight for an oral antiviral pill against COVID-19

24 Mar 2021

Statin use, but not exercise, blunts triglyceride elevation after fat meals

24 Mar 2021

Exercise does not appear to reduce postprandial triglyceridaemia (PPTG) in individuals with hypercholesteraemic metabolic syndrome (MetS) relative to metabolically healthy (MetH) controls, reveals a study. However, chronic statin medication moderates the elevations in triglyceride after a meal (ie, incremental are under the curve of PPTG), reducing the cardiovascular risk associated with atherogenic dyslipidaemia.

Statin use, but not exercise, blunts triglyceride elevation after fat meals

24 Mar 2021

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AstraZeneca-Oxford COVID-19 vaccine 79 percent effective in US trial

AstraZeneca-Oxford COVID-19 vaccine 79 percent effective in US trial

Longer interval between doses of COVID-19 vaccines: A gamble worth taking?

Longer interval between doses of COVID-19 vaccines: A gamble worth taking?

High fluctuation seen in anticoagulants use, off-label dosing stable

High fluctuation seen in anticoagulants use, off-label dosing stable

PDE5i therapy lowers risk of heart failure, death in men with CAD

PDE5i therapy lowers risk of heart failure, death in men with CAD

Metabolic surgery better than meds for T2D control?

Metabolic surgery better than meds for T2D control?

Should women stop antidepressant treatment during pregnancy?

Should women stop antidepressant treatment during pregnancy?

Margetuximab bests trastuzumab in advanced breast cancer

Margetuximab bests trastuzumab in advanced breast cancer

Predictors of main bleeding following ticagrelor

Predictors of main bleeding following ticagrelor

Hope in sight for an oral antiviral pill against COVID-19

Hope in sight for an oral antiviral pill against COVID-19

Statin use, but not exercise, blunts triglyceride elevation after fat meals

Statin use, but not exercise, blunts triglyceride elevation after fat meals