News & Updates

Both core and noncore homologous recombination mutations (HRMs) respond to platinum chemotherapy in metastatic nonpancreatic gastrointestinal (GI) cancers, which suggests benefit in the two groups, reports a study.

Wild-type gastrointestinal stromal tumours (GIST), though rare, tend to develop more frequently in older adults and commonly originate in the stomach or small intestine, a recent study has found. Though treatment options are limited, surgical resection and systemic therapy remain the principal modalities.

The combination of lenalidomide plus ixazomib in the maintenance treatment of patients with post-transplant myeloma leads to better progression-free survival (PFS) compared with lenalidomide alone in historical controls, according to a study.

First-line treatment with nivolumab – be it in combination with chemotherapy (CT) or with ipilimumab – provided overall survival (OS) benefit and durable responses than CT alone in patients with advanced oesophageal squamous cell carcinoma (ESCC), according to findings from the phase III CheckMate 648 trial.

Patients with head and neck cancer who undergo radiation therapy tend to have persistent opioid use, reveals a study, noting further investigation on early intervention to appropriately wean patients.