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Long-term ACS outcomes similar between TiNO-coated and everolimus-eluting stents
Neither titanium-nitride-oxide (TiNO)–coated stents nor third-generation everolimus-eluting stents (EES) are necessarily better than the other in the treatment of patients with acute coronary syndromes (ACS), with a study showing no significant difference in long-term outcomes following placement of TiNO-coated stents or EES.

CHIP predicts adverse outcomes in atherosclerotic CVD
Clonal haematopoiesis of indeterminate potential (CHIP) appears to independently contribute to adverse outcomes in individuals with established atherosclerotic cardiovascular disease (ASCVD), reveals a recent study, noting the high risks in TET2 and SF3B1/SRSF2/U2AF1 CHIP.

Takotsubo syndrome tied to impaired LV contractility, shortened systolic period
Patients with Takotsubo syndrome (TTS), a reversible form of heart failure with incompletely understood pathophysiology, may exhibit reduced cardiac contractility, shortened systolic period, inefficient energetics, and prolonged active relaxation but unaffected diastolic passive stiffness, a study has shown.

Triple, quadruple combos a useful strategy for early management of hypertension
Low-dose drug combinations that incorporate between three and four blood pressure (BP)-lowering medications appear to be well tolerated and effective for the initial or early management of hypertension, according to the results of a systematic review and meta-analysis.

Rivaroxaban for prophylactic anticoagulation in COVID-19 strikes out
The use of rivaroxaban in nonhospitalized patients with symptomatic COVID-19 falls short of reducing the composite endpoint of venous and arterial thrombotic events, hospitalization, and death, according to data from PREVENT-HD*.



