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Fulvestrant-palbociclib combo pre-progression improves PFS in ESR1+ mBC
Switching to a fulvestrant-palbociclib regimen prior to disease progression after detection of elevated ESR1 mutations in the blood of patients with hormone receptor-positive (HR+), HER2-negative (HER2-) metastatic breast cancer (mBC) who were receiving aromatase inhibitors (AIs) plus palbociclib extended their progression-free survival (PFS), results of the phase III PADA-1 trial showed.

More than 1 in 4 young adults test seropositive for COVID-19
A recent study has shown that more than a quarter of young adults are seropositive for SARS-CoV-2, many of whom show single positivity with IgM. Such seropositivity was higher among those who had cases of the coronavirus disease 2019 (COVID-19) in the household and those who used public transport.

Do antihypertensive drugs raise odds of COVID-19 diagnosis, death?
Antihypertensive therapy (AHT) may be used safely during the COVID-19 pandemic, as no evidence suggest that it can increase the risk of SARS-CoV-2 infection or death, according to a UK study. In addition, most classes of antihypertensives are negatively associated with COVID-19 diagnosis.

3D gonioscopy detects eyes with suspected glaucoma
The 3-dimensional (3D) deep learning-based automated digital gonioscopy system (DGS) effectively identifies eyes with suspected primary angle-closure glaucoma (PACG), demonstrating its potential for wide use in the primary eye care community for screening of patients at high risk of developing PACG, suggests a study.

The 5:2 diet: Is it worth the hype?
The benefits of the 5:2 diet – which involves limited caloric intake (500–600 kcal) for 2 nonconsecutive days per week only – mirrored those achieved with a multicomponent weight management advice, according to a UK study on adults with obesity. However, the benefits eventually waned, even when intensified with group support.




