News & Updates
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Radiofrequency vs pulsed field ablation: Which approach results in fewer stroke/TIA events?
A single-centre study has found a significantly higher incidence of stroke and transient ischaemic attacks (TIA) within 30 days among patients who underwent pulsed field ablation (PFA) relative to those who received radiofrequency ablation (RFA).

Statin-ezetimibe holds slight advantage over PCSK9is in ACS
In a systematic review and network meta-analysis (NMA), a statin-ezetimibe combination yields a more favourable LDL-C reduction and a positive trend in atherosclerotic plaque regression compared with PCSK9 inhibitors (PCSK9is) alone in individuals with acute coronary syndrome (ACS).

SONIA: Does 1L vs 2L use of CDK4/6 inhibitors improve OS in HR+, ERBB2- ABC?
A phase III randomized clinical trial (RCT) of 1,050 patients with hormone receptor–positive (HR-positive), ERBB2-negative advanced breast cancer (ABC) showed that first-line (1L) use of cyclin-dependent kinase (CDK) 4 and 6 inhibitors did not improve overall survival (OS) compared with second-line (2L) use. At the same time, a post hoc subgroup analysis suggested an OS benefit with 1L use of CDK4/6 inhibitors in premenopausal patients.





