Epleron: Dosing, Side Effect & Interaction

Indications/Uses

Symptomatic heart failure, in addition to standard therapy including β-blockers, in stable patients w/ left ventricular dysfunction (LVEF ≤40%) & clinical evidence of heart failure after recent MI; mild to moderate HTN.

Dosage/Direction for Use

Symptomatic heart failure & heart failure after recent MI Initially 25 mg once daily & titrated to the target dose of 50 mg once daily. HTN Initially 50 mg once daily, may be increased to 50 mg twice daily if BP response is inadequate.

Administration

May be taken with or without food.

Contraindications

Hypersensitivity. Serum K level >5.5 mEq/L at initiation. Co-administration w/ strong CYP3A inhibitors (eg, ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, & nelfinavir); ACE inhibitor & ARBs. CrCl ≤30 mL/min. Severe hepatic insufficiency (Child-Pugh class C). HTN: Type 2 diabetes w/ microalbuminuria. Co-administration of K supplements or K sparing diuretics (eg, amiloride, spironolactone, or triamterene). Serum creatinine >2 mg/dL in males or >1.8 mg/dL in females. CrCl <50 mL/min.

Special Precautions

Hyperkalemia.

Adverse Reactions

Left ventricular failure, atrial fibrillation; diarrhea, nausea, constipation, vomiting; asthenia; increased blood urea & blood creatinine; hyperkalaemia, hypercholesterolaemia; muscle spasms, back pain; dizziness, syncope, headache.

View ADR Reporting Link

MIMS Class

Diuretics

ATC Classification

C03DA04 - eplerenone ; Belongs to the class of aldosterone antagonists. Used as potassium-sparing diuretics.

Regulatory Classification

K

Presentation/Packing

Form

Epleron FC tab 25 mg

Packing/Price

3 × 10's

Form

Epleron FC tab 50 mg

Packing/Price

3 × 10's

Epleron

eplerenone

Manufacturer:

Fahrenheit