Aerrane

AERRANE is a volatile halogenated anaesthetic for general inhalation anaesthesia.

In order to be able to accurately control the precise concentration of AERRANE, vaporisers that have been specifically calibrated for isoflurane should be used.
Minimum alveolar concentration (MAC) of AERRANE in humans:
Age (years): Neonates
O₂ - 100%: 1.60.
O₂ + N₂O (60%): -
Age (years): 1-6 months
O₂ - 100%: 1.87
O₂ + N₂O (60%): -
Age (years): 7-11 months
O₂ - 100%: 1.80
O₂ + N₂O (60%): -
Age (years): 1-2 years
O₂ - 100%: 1.60
O₂ + N₂O (60%): -
Age (years): 3-5 years
O₂ - 100%: 1.62
O₂ + N₂O (60%): -
Age (years): 6-10 years
O₂ - 100%: 1.40
O₂ + N₂O (60%): 0.58
Age (years): 10-15 years
O₂ - 100%: 1.16
O₂ + N₂O (60%): 0.53
Age (years): 26 ± 4
O₂ - 100%: 1.28
O₂ + N₂O (70%): 0.56
Age (years): 44 ± 7
O₂ - 100%: 1.15
O₂ + N₂O (70%): 0.50
Age (years): 64 ± 5
O₂ - 100%: 1.05
O₂ + N₂O (70%): 0.37
Induction of anaesthesia: If AERRANE is used for induction of anaesthesia, a starting concentration of 0.5% is recommended. Concentrations of 1.3-3.0% usually bring about surgical anaesthesia within 7 to 10 minutes.
It is recommended that use be made of a hypnotic dose of a short acting barbiturate or another product such as propofol, etomidate, or midazolam in order to avoid coughing or laryngospasm, which can arise if induction is carried out with AERRANE alone or in combination with oxygen or with an oxygen-nitrous oxide mixture.
Maintenance of anaesthesia: Anaesthesia can be maintained during surgery using a concentration of 1.0-2.5%, with the simultaneous administration of N2O and O2.
A higher concentration of 1.5-3.5% of AERRANE is necessary if AERRANE is administered with pure oxygen.
Recovery: The concentration of AERRANE must be reduced to 0.5% at the end of the operation, or to 0% during closure of the wound to allow prompt recovery.
If all administration of anaesthetic agents has been stopped, the air passages of the patient should be ventilated several times with 100% oxygen until complete awakening occurs.
If the vector gas is a mixture of 50% O2 and 50% N2O, the volume of the minimum alveolar concentration of AERRANE is approximately 0.65%.

AERRANE is contraindicated in those patients with: With known hypersensitivity to isoflurane or to other halogenated inhalational anaesthetics.
With known or suspected susceptibility to malignant hyperthermia.
With a history of confirmed hepatitis due to a halogenated inhalational anaesthetic or a history of unexplained moderate to severe hepatic dysfunction (e.g., jaundice associated with fever, leukocytosis, and/or eosinophilia) after anaesthesia with isoflurane or other halogenated inhalational anaesthetic.
Obstetric operation.
Nonselective MA01).
In whom general anaesthesia is contraindicated.

Anaesthetics - Local & General

N01AB06 - isoflurane ; Belongs to the class of halogenated hydrocarbons. Used as general anesthetics.

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