News & Updates

High levels of cardiovascular health (CVH), as defined by Life’s Essential 8 (LE8), is associated with a lower risk of developing pulmonary hypertension (PH), suggests a study. Proteomic signatures mediate this protective effect.

Microbiome-derived deoxycholic acid (DCA) worsens portal hypertension by boosting TPH1-dependent 5-hydroxytryptamine (5-HT) biosynthesis, which activates portal vein smooth muscle cell contraction via HTR1A-GIRK3 signalling, a study has found.

A combined intrahepatic (IH) and periduodenal (PD) embolization strategy results in higher initial response rates and longer duration of remission compared with IH embolization alone in congenital heart disease (CHD) patients with protein-losing enteropathy (PLE), a study has shown.

Individuals with hypertensive disorders of pregnancy (HDP) may be at increased risk of dementia, as suggested in a retrospective cohort study.

Selection of direct-oral anticoagulants (DOACs) and risk stratification can be improved when clinicians assess both polypharmacy and potential drug interactions, especially with concomitant cardiovascular drugs and site-specific bleeding risk, suggests a study.

A polypill containing valsartan, amlodipine, and chlorthalidone (KDF1901) works better than the valsartan–amlodipine combination for improving blood pressure (BP) control in Asians with essential hypertension, according to a phase III study from South Korea.

For active smokers with newly diagnosed peripheral artery disease (PAD), complete smoking cessation lowers the risks of both cardiovascular and limb-specific adverse events, whereas partial smoking reduction offers no benefit, according to a large retrospective cohort study.