News & Updates

In patients with mantle cell lymphoma (MCL) who have achieved complete remission and undetectable minimal residual disease (MRD) following initial therapy, autologous hematopoietic cell transplantation (auto-HCT) confers no survival advantage when compared with maintenance therapy alone, as shown in the interim results of the phase III ECOG-ACRIN EA4151 trial.

Among women with low-risk ductal carcinoma in situ, the incidence of invasive cancer in the same breast does not appear to be different between those who have undergone active monitoring and those who have received a surgical procedure, according to the results of COMET trial.

Chemotherapy combined with blinatumomab (blin) delivers significant improvements in disease-free survival (DFS) in children with newly diagnosed National Cancer Institute standard risk (SR) B-cell acute lymphoblastic leukaemia (B-ALL), according to the results of the AALL1731 study presented at ASH 2024.

The addition of tafasitamab (tafa) to lenalidomide and rituximab (len+R) significantly improves progression-free survival (PFS) in patients with relapsed or refractory (R/R) follicular lymphoma (FL), as shown in a phase III study presented at ASH 2024. The safety profile of this combination is manageable and consistent with expected toxicities.

Treatment with belzutifan improves progression-free survival (PFS) and objective response rate (ORR) in East Asian patients with advanced clear-cell renal cell carcinoma (RCC) compared with everolimus, according to the updated subgroup data of the phase III LITESPARK-005 trial presented at ESMO Asia 2024.

Adjuvant use of tamoxifen is associated with a big drop in the risk of recurrence in the same breast among patients with “good-risk” ductal carcinoma in situ (DCIS) after breast-conserving surgery without radiotherapy.

Muscle or fat-free mass (FFM) decreases in patients with acute myeloid leukaemia (AML) or myelodysplastic syndrome (MDS) undergoing intensive chemotherapy despite medical nutrition therapy (MNT), reports a recent study. Fat mass, on the other hand, remains unchanged.