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Abrocitinib effectively controls AD regardless of dosing regimen
In patients with moderate-to-severe atopic dermatitis (AD), flexible dosing of abrocitinib, an oral, once-daily Janus kinase 1-selective inhibitor, appeared as beneficial as the continuous high-dose regimen. This was demonstrated in a post hoc analysis of two studies from the JADE* clinical development programme.

Multiple biomarkers may improve prediction of suicidal behaviour during depression treatment
Combinations of serum biomarkers relating to cortisol, total cholesterol, and folate, as well as interleukin (IL)-1β and homocysteine, help improve the predictability of suicide attempt and increased suicidal severity, respectively, among individuals being treated for depression, according to a study.

High polygenic risk linked to earlier treatment initiation, escalation in glaucoma
High glaucoma polygenic risk score (PRS) shows a significant association with earlier initiation or escalation of intraocular pressure (IOP)-lowering therapy, according to a study, noting the potential usefulness of genetic risk stratification in glaucoma.






