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Bipolar disorder roadmap: Navigating warning signs from childhood to adolescence in offspring of patients
Behavioural problems during childhood, along with delayed circadian rhythm, social anxiety, and mood symptoms in adolescence, may serve as early indicators of bipolar disorder in offspring of Chinese parents with the disorder, a case-control high-risk offspring study has shown.
STAMP inhibitor bests all TKIs in pivotal head-to-head CML study
In the phase III ASC4FIRST study, asciminib – the first BCR::ABL1 inhibitor to Specifically Target the ABL Myristoyl Pocket (STAMP) – trumped all investigator-selected tyrosine kinase inhibitors (IS-TKIs; imatinib, nilotinib, dasatinib, and bosutinib) for the treatment of newly diagnosed Philadelphia chromosome-positive chronic myeloid leukaemia in chronic phase (Ph+ CML-CP).
Empagliflozin reduces hepatic fat content in nondiabetic MASLD patients
Empagliflozin significantly reduces hepatic fat content vs placebo in patients with metabolic dysfunction–associated steatotic liver disease (MASLD) without diabetes, researchers from the University of Hong Kong have reported.
