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Once-weekly icodec affords greater blood sugar reduction than once-daily degludec in T2D
In the treatment of individuals with insulin-naïve type 2 diabetes (T2D), once-weekly icodec yields superior HbA1c reduction compared with once-daily degludec, according to the results of a phase IIIa trial.
Gas-filled on par with fluid-filled IGB for obesity treatment
Current Food and Drug Administration (FDA)-approved intragastric balloon (IGB) systems, the gas-filled IGB (Obalon) and the fluid-filled IGB (Orbera), demonstrate similar effectiveness for the treatment of obesity, as shown in a recent study.
Novel genetic marker predicts CHD risk in Chinese patients with T2DM
Researchers from the Chinese University of Hong Kong (CUHK) have discovered PDE1A rs10171703 as a novel genetic marker for coronary heart disease (CHD) in Chinese patients with type 2 diabetes mellitus (T2DM), indicating its potential utility for predicting CHD risk in this patient population.
Debunking the myth: There is no ‘obesity paradox’, new data suggest
Using alternative anthropometric measurements, a post hoc analysis that used data from the PARADIGM-HF* trial debunked the BMI-related ‘obesity paradox’ in a large cohort of patients with chronic heart failure with reduced ejection fraction (HFrEF).
SGLT2 inhibitors score big, this time in gout
Patients initiated on gliflozins or flozins – also called sodium-glucose co-transporter 2 (SGLT2) inhibitors – for type 2 diabetes (T2D) who were previously on metformin had reductions in the incidents of gout of up to 60 percent compared with other second-line agents in a recent study.