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A hearing aid intervention does little to reduce the incidence of dementia-level impairment in older adults with coexisting hearing loss and mild cognitive impairment (MCI), as shown in the CHOICE trial.
Individuals with hypertensive disorders of pregnancy (HDP) may be at increased risk of dementia, as suggested in a retrospective cohort study.
Use of statins is associated with a lower incidence of remote seizures following a first status epilepticus event, according to a retrospective study.
Congenital toxoplasmosis, syphilis, rubella, cytomegalovirus, or herpes simplex (TORCH) infections are rare but are associated with intellectual disability and autism, as shown in a study.
Current use of oral menopausal hormone therapy may increase the risk of venous thromboembolism (VTE) regardless of dosage and treatment duration compared with no use, according to a study.
Impaired left atrial (LA) function, particularly atrial electromechanical dissociation (AEMD), appears to increase the risk of cerebrovascular events in patients with transthyretin amyloid cardiomyopathy (ATTR-CM), suggests a study.
Long-term exposure to road traffic noise appears to contribute to an increased risk of Parkinson’s disease (PD), and this risk is mitigated by having a quiet facade, according to a Danish nationwide prospective cohort study.
The selective, oral, central nervous system-penetrant reversible RIPK1 inhibitor SAR443820 appears to have limited clinical benefit in amyotrophic lateral sclerosis (ALS) and is even associated with greater hepatic enzyme increase, according to the phase II HIMALAYA trial.
The novel oral orexin 2 receptor (OX2R) agonist alixorexton has demonstrated clinical benefits in patients with narcolepsy type 1, yielding improvements in wakefulness, excessive daytime sleepiness, and cataplexy, according to the phase II Vibrance-1 trial.
Supplementation with high-dose folic acid appears beneficial to pregnant women with epilepsy being treated with antiseizure medications (ASMs), having been associated with a lower incidence of adverse offspring outcomes in an observational study from China.
