News & Updates

High levels of cardiovascular health (CVH), as defined by Life’s Essential 8 (LE8), is associated with a lower risk of developing pulmonary hypertension (PH), suggests a study. Proteomic signatures mediate this protective effect.

Higher cardiorespiratory fitness and engaging in moderate-to-vigorous intensity physical activity (MVPA) during young or middle adulthood do not appear to reduce the risk of severe vasomotor symptoms (VMS) during menopause, as shown in a study.

Periconception parental vitamin B12 and postconception maternal red blood cell (RBC) folate are predictive of lower birth defect prevalence, suggests a study.

Microbiome-derived deoxycholic acid (DCA) worsens portal hypertension by boosting TPH1-dependent 5-hydroxytryptamine (5-HT) biosynthesis, which activates portal vein smooth muscle cell contraction via HTR1A-GIRK3 signalling, a study has found.

Arginine therapy is no better than placebo in terms of improving outcomes in children and young adults with sickle cell disease (SCD) who are experiencing acute pain episodes, according to the phase III STArT trial.

Patient-reported outcomes among young adults with persistent knee problems after anterior cruciate ligament reconstruction (ACLR) improve with physiotherapist-supervised exercise therapy plus education compared with a single education session and self-directed exercise resource, according to a study.

A generalist-led care, the Integrated General Hospital (IGH) care model, demonstrates a numerically lower number of deaths and clinical outcomes comparable to a specialist-led care, the usual care model, as shown in a Singapore study. Patient care experiences with IGH are also positive.

The American College of Rheumatology/European Alliance of Associations for Rheumatology (ACR/EULAR) Total Improvement Score (TIS) may be used in research autoimmune inflammatory myopathies (AIM), according to a study.