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Dual glucagon/GLP-1 RA survodutide shows broad benefits in phase III obesity & MASLD trials
Survodutide, a glucagon receptor–glucagon-like peptide-1 (GLP-1) receptor dual agonist, significantly reduces body weight and liver/visceral fat in individuals with obesity as well as those with obesity and at-risk metabolic dysfunction–associated steatotic liver disease (MASLD) in the phase III SYNCHRONIZE-1 and SYNCHRONIZE-MASLD trials. The data, presented at ADA 2026, also demonstrate improvements in cardiometabolic parameters indicating broad benefits associated with survodutide treatment.

Bile acid reductions with odevixibat tied to improved LFTs in patients with PFIC2
In individuals receiving odevixibat for progressive familial intrahepatic cholestasis 2 (PFIC2), also known as bile salt export pump (BSEP) deficiency, reductions in serum bile acid (sBA) levels correlated with improvements in key liver function tests (LFTs), according to a post hoc subgroup analysis presented at ESPGHAN 2026.






