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Four-drug pill beats three separate meds in difficult-to-treat hypertension
For individuals with difficult-to-treat hypertension who are struggling with three separate medications, a single pill that combines four blood pressure (BP)-lowering drugs may help with BP control, as shown in the phase III QUADRO trial.

SGLT-2 inhibitors may prevent dementia in adults with T2D
Initiation of sodium-glucose cotransporter-2 (SGLT-2) inhibitors results in a 35-percent reduced risk of dementia compared with dipeptidyl peptidase-4 (DPP-4) inhibitors in individuals with type 2 diabetes (T2D) aged 40–69 years, according to a study. In addition, greater benefits are seen with longer treatment duration.

Tapinarof safe, efficacious for moderate-to-severe AD in children, adults
Treatment with tapinarof cream 1% once daily demonstrates significant efficacy with a favourable safety profile among adults and children with moderate-to-severe atopic dermatitis (AD), a study has shown.

Colchicine on par with NSAID for pericarditis prevention in HFrEF, CAD
The incidence of pericarditis recurrence or documentation of incessant symptoms within 12 months of the index hospitalization does not differ between heart failure (HF) patients treated with colchicine monotherapy and those who received NSAID monotherapy.

Add-on acalabrutinib prolongs PFS in older patients with untreated MCL
In older patients with untreated mantle cell lymphoma (MCL), the addition of the Bruton tyrosine kinase (BTK) inhibitor acalabrutinib to bendamustine and rituximab (ABR) conferred a statistically significant and clinically meaningful improvement in progression-free survival (PFS) with a favourable trend for overall survival (OS), findings from the phase III ECHO trial have shown.



