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12-year review of HK Breast Cancer Registry: Neoadjuvant chemo effective in stage ≥II, HER2-positive and triple-negative disease
A 12-year review of Hong Kong Breast Cancer Registry (HKBCR) records of patients diagnosed with breast cancer in 2006–2017 showed that neoadjuvant chemotherapy (NAC) was effective in tumour downstaging, with one-fifth of patients subsequently achieving pathological complete response (pCR) in the breast and axillary lymph nodes. Patients with HER2-positive (nonluminal) and triple-negative disease were most likely to achieve pCR.

Serum osteopontin levels predicts response to treatment in unresectable HCC
Among patients with unresectable hepatocellular carcinoma (HCC) scheduled to receive standard combination therapy with atezolizumab plus bevacizumab, those with high levels of serum osteopontin at baseline are likely to have poor response to treatment, as shown in a study.

Neoadjuvant olaparib feasible in BRCA-mutated ovarian cancer
Neoadjuvant treatment with the PARP* inhibitor olaparib yielded encouraging outcomes in patients with BRCA-mutated ovarian cancer, with all participants completing two cycles of therapy followed by surgery in the NOW trial presented at SGO 2023.





