Toloxatone: Uses, Dosage, Side Effects and More

This information is not country-specific. Please refer to the Hong Kong prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Depression

Adult: 200 mg tid.

Contraindications

Pregnancy, lactation.

Special Precautions

Stop toloxatone 6 hr before general anaesthesia. Monitor BP at the start of treatment.

Adverse Reactions

Dysuria, nausea, constipation, vertigo, insomnia.
Potentially Fatal: Fulminant hepatitis.

Drug Interactions

Increased risk of serotonin syndrome with SSRI, TCA. Increased BP with sympathomimetics. Increased concentration of triptans.
Potentially Fatal: Increased risk of hypertension and CNS excitation when given with MAOI, wait for 15-20 days after end of MAOI therapy before starting toloxatone.

Food Interaction

Increased BP with large amounts of tyramine-rich food.

Action

Description:
Mechanism of Action: Toloxatone is a reversible inhibitor of monoamine oxidase type-A (RIMA).

MIMS Class

Antidepressants

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