History of angioedema due to an ACE inhibitor, patients who undergo LDL apheresis using dextran cellulose sulfate or hemodialysis w/ acrylonitrile methallyl sulfonate Na membrane. Pregnancy, lactation.
Renal impairment, bilateral renal arterial stenosis, cerebrovascular disorders, elderly. Severe HTN, patients who undergo hemodialysis, diuretic therapy, patients on strict dietary salt restriction. May impair ability to drive or operate machinery. Administration is not recommended w/in 24 hr prior to surgery.
K supplements or K-sparing diuretics. May potentiate hypotensive effects when used w/ diuretics or other antihypertensives. May increase serum lithium conc, NSAIDs, hypotensives, nitrates. Undergoing LDL apheresis w/ dextran cellulose sulfate adsorption, dialysis w/ acrylonitrile methallyl sulfonate Na membrane.
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