Decreases lithium excretion. Increases risk of ventricular arrhythmias w/ class Ia & III, antiarrhythmics & antipsychotics. Increases antihypertensive effect w/ baclofen, imipramine-like antidepressants, neuroleptics. Reduces antihypertensive effect of indapamide w/ NSAIDs including COX-2 selective inhibitors & high-dose salicylic acid (≥3 g/day), costicosteroids, tetracosactide. Risk of sudden hypotension &/or acute renal failure w/ ACEIs. Increases risk of hypokalaemia w/ amphotericin B IV, gluco- & mineralocorticoids, tetracosactide, stimulant laxatives, digitalis prep, K-sparing diuretics. Increases risk of metformin-induced lactic acidosis. Increases risk of acute renal failure w/ iodinated contrast media. Increases plasma creatinine w/ ciclosporin, tacrolimus. Decreases urinary elimination of Ca w/ Ca salts.
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