Levofloxacin Kabi Dosage/Direction for Use

Levofloxacin Kabi solution for infusion is administered by slow intravenous infusion once or twice daily. The dosage depends on the type and severity of the infection and the susceptibility of the presumed causative pathogen.
Treatment with Levofloxacin Kabi after initial use of the intravenous preparation may be completed with an appropriate oral presentation as considered appropriate for the individual patient. Given the bioequivalence of the parenteral and oral forms, the same dosage can be used.
Posology: The following dose recommendations can be given for Levofloxacin Kabi: Dosage in patients with normal renal function (creatinine clearance >50 ml/min): See Table 3.

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Special populations: Impaired renal function (creatinine clearance ≤50 ml/min): See Table 4.

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Impaired liver function: No adjustment of dose is required since levofloxacin is not metabolised to any relevant extent by the liver and is mainly excreted by the kidneys.
Elderly population: No adjustment of dose is required in the elderly, other than that imposed by consideration of renal function (see Tendinitis and tendon rupture and QT interval prolongation under Precautions).
Paediatric population: Levofloxacin Kabi is contraindicated in children and growing adolescents (see Contraindications).
Method of administration: Levofloxacin Kabi solution for infusion is only intended for slow intravenous infusion; it is administered once or twice daily. The infusion time must be at least 60 minutes for 500 mg Levofloxacin Kabi solution for infusion (see Precautions).
For incompatibilities, see Incompatibilities under Cautions for Usage. For compatibility with other infusion solutions, see Pharmaceutical precautions under Cautions for Usage.