Primary hyperlipidemia types IIa, IIb, III, IV & V. Secondary hyperlipidemia eg, severe hypertriglyceridemia.
Dosage/Direction for Use
Bezalip 1 tab tds, may be reduced to 1 tab bd in case of good therapeutic response especially in hypertriglyceridemia. Bezalip Retard 1 tab daily. Limited renal function, use only Bezalip.
Administration
Should be taken with food: Swallow whole, do not chew/crush.
Contraindications
Liver diseases (except fatty liver), gallbladder diseases w/ or w/o cholelithiasis. Severe renal impairment (serum creatinine >6 mg/100 mL or CrCl <15 mL/min for Bezalip or >1.6 mg/100 mL or 136 micromol/L for Bezalip Retard). Nephrotic syndrome. Patients undergoing dialysis. Combination therapy w/ HMG-CoA reductase inhibitors in patients w/ predisposing factors for myopathy. Photoallergic or phototoxic reactions to fibrates. Pregnancy & lactation. Elderly (Bezalip Retard).
Special Precautions
Discontinue if adequate response has not been achieved w/ in 3-4 mth. Concurrent treatment w/ oestrogens or oestrogen-containing OC, HMG-CoA reductase inhibitors, cholestyramine. Impaired renal function, hypoalbuminaemia. Childn.
Adverse Reactions
Decreased appetite, transient GI disturbances, myopathy, rhabdomyolysis.